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KMID : 1059519990430010104
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Journal of the Korean Chemical Society
1999 Volume.43 No. 1 p.104 ~ p.109
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Development of Novel Diagnostic Testing Strips for Measuring Leukocyte Levels in Urine
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Park Soo-Min
Park Chung-Oh
Jang Won-Cheoul
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Abstract
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A number of leukocytes increases when infected by a germ or virus. Detection of leukocyte levels can indicate of such medical informations as urogenital tract infection or other dysfunction. In this study, pentyl-3-thiophene-carboxlyate (PTC), pentyl-8-quinolinecarboxylate (PQC), and 2-Phenyl-4(N-tosyl-alanyloxyl)-thiazole (PTT) were synthesized, and the test strips were prepared with these substrates for quantifying leukocytes in urine. Among these substrates, the PTT test strip prepared in 0.5% borate buffer pH 8.0, 0.03% PTT, 0.1-0.8% PVP, and 1% decanol showed not only better color reaction but also an excellent application possibility to be used in automatic urine analyzer.
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